The Notch signalling pathway controls differentiation of hair cells and supporting cells in the vertebrate inner ear.Here, we have investigated whether Numb, a known regulator of Notch activity in Drosophila, is involved in this process in the embryonic chick.The chicken homologue of Numb is expressed throughout the otocyst at early stages of devel
Summary: The dynamic process by which nuclear RNAi engages a transcriptionally active target, before the repressive state is stably established, remains largely a mystery.Here, we found that the onset of exogenous dsRNA-induced nuclear RNAi in C.elegans is a transgenerational process, and it requires a putative histone Foundation methyltransferase
The purpose of the Foundation current study is to find exact travelling wave solutions of the Rosenau equation.By the use of the extended auxiliary equation method, various exact solutions are obtained in terms of Jacobi elliptic functions and exponential functions.Moreover, several solitary and periodic wave solutions are given as special cases.Wh
ABSTRACT Throughout life, humans experience repeated exposure to viral antigens through infection and vaccination, resulting in the generation of diverse, antigen-specific antibody repertoires.A paramount feature of antibodies that enables their critical contributions in counteracting recurrent and novel pathogens, and consequently fostering their
Mutations in the gene drop-dead (drd) cause diverse phenotypes in adult Drosophila melanogaster including early lethality, neurodegeneration, tracheal defects, gut dysfunction, reduced body mass, and female sterility.Despite the identification of the drd gene itself, the causes of early lethality and neurodegeneration in the mutant flies remain unk